After having a dry garage floor for a number of years, a tiny--one
drop per day--spot is showing up under my 2.1's transmission. I
recognize the grease as the clear Amzoil I use in the transmission.
It isn't engine oil. I replaced the axle seals last summer, and it
doesn't appear to be leaking from either of them.

I had a leaking rear engine seal in 2003 and had the clutch and front
transmission seal replaced then, so the one that's in there isn't
that old. The transmission, with 215000 on it, has never been opened
but it shifts well and runs quietly. Should I presume that if the
seal is wearing out, that whatever transmission parts keep the shaft
from bouncing around are having problems and thus are causing the
seal to fail, or should I just replace the seal and not worry about
the condition of the transmission?

I put a seal softener in my wife's Acura when it leaked and that
worked, likewise with my mom's Buick. But those are both automatics.
Is there any reason to believe it would help my Vanagon's manual
transmission, or any reason to avoid it?

Jim