Should wheel alignments be done with an unladen van?

(Or should I load it up with some concrete blocks, etc, to simulate the
kind of load that the van will carry on road trips?)

Any special considerations for an alignment?

New tires: Continental Vanco Four Season 185R14C rated D (load range 102 /
100 Q) are rated for 1874 kg at 65psi.

What pressure would you run them?

(I have gone to: 45 front, 49 rear, psi.)
(The shop inflated them to: 34, 36, 40 and 42.  Or, random, in other words.)

Any advice welcome.

cheers,
gab
86 Westy 2.1 WBX